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目的研究微创血肿清除术治疗脑出血患者过程中血清白细胞介素-6(IL-6)及基质金属蛋白酶-9(MMP-9)的动态变化,并对微创术的疗效进行评价。方法脑出血微创术患者及非手术患者各30例,采用酶联免疫吸附法分别于入院时及发病后2、7、14 d测定血清IL-6及MMP-9的含量,分析微创术对脑出血患者其二者表达水平动态变化的影响。结果脑出血患者发病后6 h内血清MMP-9和IL-6水平增高,在2 d时血清MMP-9和IL-6水平均达到高峰,对照组升高幅度不明显(P<0.05),微创组在7、14 d血清MMP-9和IL-6下降明显(P<0.05),而对照组则维持较高水平,微创组临床疗效明显优于对照组(P<0.01)。结论微创术后血清IL-6和MMP-9含量显著降低,可作为评价脑出血微创术治疗效果的生物学指标。
Objective To study the dynamic changes of serum interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) in patients with cerebral hemorrhage after minimally invasive hematoma removal and evaluate the curative effect of minimally invasive surgery. Methods Thirty patients with intracerebral hemorrhage minimally invasive surgery and non-surgical patients were enrolled in this study. Serum IL-6 and MMP-9 levels were measured by enzyme-linked immunosorbent assay at admission and at 2, 7 and 14 days after onset. On the dynamic changes of the expression of both in patients with intracerebral hemorrhage. Results Serum levels of MMP-9 and IL-6 increased significantly within 6 hours after onset of ICH in patients with ICH. The level of serum MMP-9 and IL-6 peaked at 2 days, but not in control group (P <0.05) The levels of serum MMP-9 and IL-6 in the minimally invasive group decreased significantly on the 7th and 14th days (P <0.05), while the control group maintained a high level. The clinical efficacy of the minimally invasive group was significantly better than that of the control group (P <0.01). Conclusion The serum levels of IL-6 and MMP-9 in patients after minimally invasive surgery are significantly lower, which may be used as a biological index to evaluate the therapeutic effect of minimally invasive intracerebral hemorrhage.