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作者分离了丁香的抗血小板聚集成分。以MS和~1HNMR确定这些成分是丁香子酚(1)和丁香子酚乙酸酯(la)。两者对花生四烯酸(AA)、肾上腺素和胶原蛋白所诱导的血小板聚集有强烈的抑制作用,并呈剂量依赖关系。(1)和(1a)消灭AA诱导的血小板聚集的量分别为7.6μmol和15μmol。在全血中,15μmol的(1a)可消灭AA诱导血小板聚集和ATP的释放。15.2μmol的(1)和12μmol的(1a)可抑制肾上腺素诱导的血小板聚集第Ⅱ期。AA诱导产生不可逆转的血小板聚集,但若预先以(1)(1.25～2.50μg PRP)处理,血小板则不聚集,以AA刺激,血小板颗粒和糖原含量仍然正常。由此可见,血小板虽以AA刺
The author isolated the anti-platelet aggregation component of cloves. These components were confirmed by MS and ~1H NMR to be eugenol (1) and eugenol acetate (la). Both have a strong inhibitory effect on platelet aggregation induced by arachidonic acid (AA), epinephrine, and collagen in a dose-dependent manner. (1) and (1a) The amount of AA-induced platelet aggregation was 7.6 μmol and 15 μmol, respectively. In whole blood, 15 μmol of (1a) can eliminate AA induced platelet aggregation and ATP release. 15.2 μmol of (1) and 12 μmol of (1a) inhibited epinephrine-induced platelet aggregation in Phase II. AA induces irreversible platelet aggregation, but platelets do not aggregate if treated with (1) (1.25 to 2.50 μg PRP) in advance, and platelet granules and glycogen content are still normal with AA stimulation. It can be seen that platelets are punctured with AA