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目的:探讨蝴蝶霜治疗黄褐斑的作用机理。方法:将实验小鼠随机分成治疗组和对照组,测定模型小鼠受试皮肤组织中的超氧化物歧化酶(SOD)活性和过氧化脂质(LPO)及脂褐质和羟脯氨酸的含量,并进行分析。结果:经蝴蝶霜治疗后SOD酶活性和羟脯氨酸含量明显增加,与治疗前比较,具有显著性差异(P<0．01);而小鼠治疗前皮肤组织中LPO和脂褐质含量治疗后明显降低,与治疗前比较,具有显著性差异(P<0．01)。结论:蝴蝶霜能提高局部皮肤组织中SOD酶活性和羟脯氨酸含量,使LPO和脂褐质含量明显降低,消除多余自由基,从而抑制黄褐斑的产生。
Objective: To explore the mechanism of action of butterfly cream on chloasma. METHODS: The experimental mice were randomly divided into treatment and control groups to determine superoxide dismutase (SOD) activity and lipid peroxidation (LPO), lipofuscin, and hydroxyproline in skin tissue of model mice. The content is analyzed. Results: SOD enzyme activity and hydroxyproline content increased significantly after treatment with butterfly cream, and there was significant difference compared with before treatment (P<0.01). However, the content of LPO and lipofuscin in skin tissue before treatment of mice was significant. Significantly lower after treatment, compared with before treatment, there was a significant difference (P <0.01). Conclusion: Butterfly Cream can increase the SOD enzyme activity and hydroxyproline content in local skin tissue, significantly reduce LPO and lipofuscin content, eliminate excess free radicals, and thus inhibit the production of chloasma.