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目的 观察利多卡因或联用可待因方法 ,对支气管动脉注入抗癌药液致刺激性咳嗽的预防作用。方法 43例肺癌患者 ,随机分为三组 ,A组 12例 :灌注抗癌药前 ,给予 0 .4～ 0 .5 %利多卡因 5ml ;B组 14例 :灌注前 2 0min含服可待因 3 0mg ,再按A组方法 ;C组 :先经导管注入 5ml生理盐水。 结果 A、B组有效率明显高于C组 (P <0 .0 5和P <0 .0 1) ,B组镇咳作用时间长于A组。结论 利多卡因有较好的预防或减轻抗癌药对支气管动脉所致刺激作用 ,但从安全用药和作用时间考虑 ,建议采用与可待因联用的方法
Objective To observe the preventive effect of lidocaine or combined use of codeine on bronchial arteries injected with anticancer drug solution to induce irritant cough. Methods Forty-three patients with lung cancer were randomly divided into three groups. Twelve patients in group A received 0.5 to 0.5% lidocaine 0.5 ml before infusion of anticancer drugs; 14 patients in group B: 20 minutes before infusion Because of 30mg, according to A group method again; C group: First inject 5ml normal saline through the catheter. Results The effective rates of group A and B were significantly higher than those of group C (P <0.05 and P <0.01). The antitussive effect of group B was longer than that of group A. Conclusion Lidocaine has a good effect in preventing or alleviating the bronchial artery-induced irritant effects of anticancer drugs. However, considering the safe use of drugs and the duration of action, it is recommended to use a combination of codeine and codeine.