疟疾是危害人类健康的重要寄生虫病。据统计,全球约有40%人口受到威胁,每年发病人数为2·5~3亿,其中死亡人数约200万[1]。对多种抗疟药具有抗性的恶性疟原虫正迅速扩散。因此,研制并开发新型抗疟药对控制全球疟疾具有重大意义。铁螯合剂作为一种新型抗疟化合物,近年来备受关注 Malaria is an important parasitic disease that endangers human health. According to statistics, about 40% of the world’s population are threatened with 25 to 300 million people a year, of which about 2 million die [1]. Plasmodium falciparum, which is resistant to various antimalarial drugs, is rapidly spreading. Therefore, developing and developing new types of anti-malaria drugs is of great importance for controlling global malaria. As a new type of antimalarial compound, iron chelators have attracted much attention in recent years