论文部分内容阅读
目的观察不同剂量氧化苦参碱(OMT)对急性心肌梗死(AMI)大鼠心室重构的防治作用。方法SD大鼠30只均分5组,除假手术组外,其他4组采用结扎冠状动脉左前降支的方法复制大鼠AMI模型后,其中3组分别用三种剂量OMT灌胃,8周后检测心指数、心肌重构指数、胶原含量并进行病理组织学检查,分析心室重构的程度。结果冠脉结扎8周后,模型组大鼠心室重构各项指标与假手术组相比差异有统计学意义(P<0.01);OMT各组大鼠心室重构各项指标与模型组相比差异有统计学意义(P<0.05或P<0.01)。结论OMT能够有效延缓心脏结构的变异,抑制胶原沉积,对AMI后心室重构具有一定的预防作用。
Objective To observe the preventive and therapeutic effects of different doses of oxymatrine (OMT) on ventricular remodeling in rats with acute myocardial infarction (AMI). Methods Thirty SD rats were divided into five groups. Except the sham operation group, the other four groups were given AMI model by ligating the left anterior descending artery of coronary artery. Three groups were given orally with three doses of OMT, Cardiac index, myocardial remodeling index, collagen content were detected and histopathological examination was performed to analyze the degree of ventricular remodeling. Results After coronary artery ligation for 8 weeks, the indexes of ventricular remodeling in model group were significantly different from those in sham-operation group (P <0.01). The indexes of ventricular remodeling in OMT group were significantly lower than those in model group The difference was statistically significant (P <0.05 or P <0.01). Conclusion OMT can effectively delay the variation of cardiac structure, inhibit the deposition of collagen and prevent ventricular remodeling after AMI.