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β-血小板球蛋白(βTG)和血小板第4因子(PF_4)存在于血小板α颗粒内,是血小板的特异蛋白,随血小板的聚集或破坏而释入血中,其血浆水平可作为血小板体内活化的一个指标,血小板内βTG 和 PF_4反映此二蛋白质在贮存池的含量。本文就血小板减少症的血浆及血小板内βTG 和 PF_4水平的变化及临床意义作一综述。一、对血小板减少症的鉴别诊断Dawes 等报道血浆βTG、PF_4的正常值分别为((?)±SD,ng/ml)30.7±13.7和13.9±6。其浓度取决于它们在血浆中的进
β-thromboglobulin (βTG) and platelet factor 4 (PF_4) are present in platelet α particles and are platelet-specific proteins that are released into the blood following platelet aggregation or disruption and whose plasma levels act as platelets in vivo One of the indicators, platelet βTG and PF_4, reflects the amount of this two protein in the reservoir. This article reviews the changes and clinical significance of βTG and PF_4 in plasma and platelets of thrombocytopenia. First, the differential diagnosis of thrombocytopenia Dawes et al reported plasma βTG, PF_4 normal values were (±) SD, ng / ml) 30.7 ± 13.7 and 13.9 ± 6. Its concentration depends on their progress in plasma