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应用肌肉机械－电换能器和Ｇｉｌｓｏｎ生理记录仪，观察ＲＵ４８６对假孕４ｄ兔离体输卵管平滑肌的收缩效应。结果显示：（１）ＲＵ４８６可直接作用输卵管平滑肌，使其收缩频率增加，而未明显改变收缩张力及振幅，与在体肌内注射ＲＵ４８６观察到的结果相似；（２）ＲＵ４８６部分抑制ｃａ~（２＋）诱发的平滑肌收缩活动，它还与Ｖｅｒａｐａｍｉｌ诱发的抑制效应有协同作用，与ＮＥ诱发的收缩张力有拮抗作用，而对Ｆｏｒｓｋｏｌｉｎ诱发的效应未产生任何影响。以上结果表明，ＲＵ４８６对输卵管平滑肌的作用似乎是改变细胞内游离Ｃａ（２＋）的结果，可能干扰Ｃａ（２＋）的流入、或／和内质网Ｃａ（２＋）释放以及Ｃａ（２＋）－Ｉｐ３信息传递机制。
The contractile effect of RU486 on the isolated fallopian tube smooth muscle in 4-day pregnant rabbits was observed by muscle mechanical-electrical transducer and Gilson physiological recorder. The results showed that: (1) RU486 could directly affect the tubal smooth muscle and increase the contraction frequency without significantly changing the contractive tension and amplitude, which was similar to RU486 in vivo; (2) 2+) -induced smooth muscle contractile activity. It also has a synergistic effect with the Verapamil-induced inhibitory effect and antagonizes NE-induced contractile tension without any effect on the Forskolin-induced effect. The above results suggest that the effect of RU486 on fallopian tube smooth muscle appears to be a consequence of altering intracellular free Ca (2+), possibly interfering with Ca (2+) influx and / or Ca (2+) release and Ca (2 +) - Ip3 Information transfer mechanism.