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目的 探讨乌鲁木齐市地区不同民族、不同病程和不同类型癫痫患儿的特异性体液免疫变化及 Ig G亚类有否差异。方法 采用 EL ISA法和统计分析法。结果 乌鲁木齐地区癫痫患儿 Ig A水平明显低于健康儿 ;维吾尔族癫痫儿 Ig G、Ig A、Ig M、Ig G1 、Ig G2 、Ig G4与汉族儿相比无显著差别 ,但 Ig G3明显低于汉族组。病程 1a以下与 1a以上癫痫患儿特异性体液免疫及 Ig G亚类无显著差异。原发癫痫儿 Ig M、Ig G1 、Ig G2 、Ig G4与继发癫痫儿相比无显著差别 ,但 Ig G、Ig A、Ig G3显著低于继发组。结论 低水平的 Ig A、Ig G3可能是不同类型癫痫患儿发病机制的环节之一。
Objective To investigate the specific humoral immune changes and IgG subtypes in children of different ethnic groups, different course of disease and different types of epilepsy in Urumqi. Methods ELISA method and statistical analysis method. Results The level of IgA in children with epilepsy in Urumqi was significantly lower than that in healthy children. The Ig G, Ig A, Ig M, Ig G1, Ig G2 and Ig G4 in Uighur epilepsy children were not significantly different from those in Han children, but Ig G3 was significantly lower In the Han group. There was no significant difference in specific humoral immunity and IgG subgroups between children with epilepsy above la and duration 1a. There were no significant differences in Ig M, Ig G1, Ig G2, Ig G4 in primary epilepsy compared with those in secondary epilepsy, but Ig G, Ig A and Ig G3 in primary epilepsy were significantly lower than those in secondary group. Conclusion Low levels of Ig A and Ig G3 may be one of the pathogenesis in children with different types of epilepsy.