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检测了17例急性血吸虫病、14例慢性血吸虫病和25例晚期血吸虫病患者外周血单核细胞在体外经 PHA 和血吸虫抗原诱生白细胞介素2(IL-2)的水平。急性组和慢性组经 PHA 诱生的 IL-2水平与对照组无显著性,而晚期组明显降低;急性组由血吸虫抗原诱生出较高水平的 IL-2,慢性组和晚期组由血吸虫抗原刺激产生的 IL-2水平虽然显著低于急性组,但明显高于对照组。提示急性和慢性患者的特异性细胞免疫分别呈增高和降低调节,晚期患者的特异性和非特异性细胞免疫均显著降低。IL-2在血吸虫病的免疫调控中起重要作用。
The levels of interleukin 2 (IL-2) induced by PHA and schistosome antigen in peripheral blood mononuclear cells from 17 acute schistosomiasis patients, 14 chronic schistosomiasis patients and 25 late schistosomiasis patients were detected. The levels of IL-2 induced by PHA in acute group and chronic group were not significantly different from those in control group, but significantly lower in late group. In acute group, higher levels of IL-2 were induced by schistosome antigen, while in chronic group and late group, Although the level of IL-2 produced by stimulus was significantly lower than that of acute group, it was significantly higher than that of control group. Tip acute and chronic patients with specific cellular immunity were increased and decreased regulation, advanced patients with specific and nonspecific cellular immunity were significantly reduced. IL-2 plays an important role in the immunological regulation of schistosomiasis.