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目的:探讨使用细胞因子诱导的杀伤细胞(cytokine-induced killer cells,CIK细胞)免疫治疗老年中晚期胃癌的副反应及其处理方法。方法:采用生物技术诱导培养CIK细胞,经培养后的CIK细胞回输给老年中晚期胃癌患者,同时观察输注后的临床反应。结果:在回输后29例老年中晚期胃癌患者中PR 8例,MR 9例,sD 7例,PD 5例,总缓解率为58．6％。患者的全身反应及局部反应包括寒战13例,发热9例,恶心呕吐1例,全身不适3例,经对症处理后无一例患者出现休克、毛细血管渗漏综合征、皮疹与血尿常规、肝肾功能异常。结论:用自体CIK细胞治疗老年中晚期胃癌,可使老年中晚期胃癌患者的临床症状和体征得到改善,治疗中的副反应经对症处理可以缓解。
Objective: To investigate the immunotherapy of advanced gastric cancer with cytokine-induced killer cells (CIK cells) and its treatment methods. Methods: CIK cells were induced by biotechnology, and CIK cells were transfused to elderly patients with advanced gastric cancer. The clinical responses after infusion were also observed. Results: Among the 29 elderly patients with advanced gastric cancer after reperfusion, 8 were PR, 9 were MR, 7 were sD and 5 were PD. The overall response rate was 58.6%. Patients with systemic and local reactions, including chills in 13 cases, 9 cases of fever, nausea and vomiting in 1 case, 3 cases of general malaise, after symptomatic treatment without a patient with shock, capillary leak syndrome, rash and hematuria, liver and kidney Abnormal function. Conclusion: The treatment of elderly patients with advanced gastric cancer with CIK cells can improve the clinical symptoms and signs of elderly patients with advanced gastric cancer, the side effects of treatment can be alleviated by symptomatic treatment.