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鉴于近些年本县小月龄婴儿及成人麻疹发病出现增多趋势,我们于1997年对1973-1975年出生的产妇及所生婴儿的麻疹免疫水平,以及6月龄婴儿的麻疹疫苗(MV)免疫应答反应,进行了血清学监测.结果:170对产妇及婴儿麻疹血凝抑制(HI)抗体阳性率分别为91.76%及93.53%,几何平均滴度(GMT)分别为1:7.53及1:8.54;139名出生时HI抗体阳性的婴儿,在6月龄时HI抗体阴转率达99.28%;31名6月龄婴儿免疫前HI抗体均<1:2,免疫后1个月HI抗体阳转率达100%,GMT为1:20.01.鉴于上述监测结果及当前麻疹流行特征,作者建议将现行婴儿麻疹疫苗初免由8月龄提前到6月龄.对预防本县出现麻疹流行提出控制对策:使外省籍流动人口中20岁以下人群MV接种率应达80%以上;对散发病例的儿童接触者和暴发点周围30岁以下人群做应急接种;当发病率>10/10万时,对流行波及范围内6-7月龄婴儿提前初免.
In view of the increasing incidence of measles in small-month-old infants and adults in this county in recent years, we analyzed the measles immunity level of maternal and newborn infants born in 1973-1975 and the measles vaccine (MV) of 6-month-old infants in 1997, Immune response to serological surveillance. Results: The positive rates of HI antibody for maternal and infant measles were 91.76% and 93.53%, respectively. The geometric mean titers (GMTs) were 1: 7.53 and 1: 8.54, respectively. At 6 months of age, the HI antibody negative rate was 99.28% in HI-positive infants at birth. The HI antibody of 31 6-month-old infants was <1: 2 before immunization, and the positive rate of HI antibody one month after immunization Up to 100%, GMT is 1: 20.01. In view of the above monitoring results and the current epidemiological characteristics of measles, the author suggests that the current exemption for infant measles vaccine be advanced from 8 months to 6 months of age. To prevent the occurrence of measles epidemic in this county to put forward control measures: the migrant population of other provinces in the population under the age of 20 MV vaccination rate should reach more than 80%; on the distribution of cases of child contacts and outbreaks around the age of 30 people under emergency vaccination; Incidence of> 10 million when prevalent within the spread of 6 - 7 month-old infants early premature.