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目的 : 探讨早期诊断系统性红斑狼疮 (SLE)肾脏损伤的方法。方法 : 采用速率散射比浊法测定 1 8例尿蛋白定性阴性和 42例尿蛋白定性阳性SLE患者晨尿转铁蛋白 (TF)、尿微量白蛋白 (UMA)和免疫球蛋白G(IgG)。结果 : 正常对照组 (n =45 )晨尿TF为 0 .48± 0 .46mg/L ,UMA为 7.1± 6 .4mg/L和IgG为 3.3± 2 .2mg/L。尿蛋白定性阴性SLE组 (n =1 8)晨尿TF为 2 .6± 3.2mg/L ,UMA为 5 0± 6 4mg/L和IgG为 1 5 .2± 1 0mg/L ,该组患者TF、UMA和IgG均显著高于对照组 (P <0 .0 1 ) ,三项指标联合检测在该组SLE中阳性率达 89%。尿蛋白定性阳性组三项指标均极显著高于对照组 ,各项检出率均达1 0 0 %。结论 : 联合检测晨尿TF、UMA和IgG是诊断SLE肾脏早期损伤灵敏、可靠的实验指标
Objective: To explore the early diagnosis of systemic lupus erythematosus (SLE) kidney damage. Methods: The morning urine transferrin (TF), urine microalbuminuria (UMA) and immunoglobulin G (IgG) were measured by rate nephelometry in 18 patients with positive urine protein and 42 patients with positive urine protein. Results: The morning urine TF of normal control group (n = 45) was 0.48 ± 0.46mg / L, UMA was 7.1 ± 6.4mg / L and IgG was 3.3 ± 2.2mg / L. Urine protein qualitative negative SLE group (n = 18) morning urine TF was 2.6 ± 3.2mg / L, UMA was 50 ± 6 4mg / L and IgG was 15.2 ± 10mg / L, the group of patients TF, UMA and IgG were significantly higher than those in the control group (P <0.01). The positive rates of three markers in the SLE group were 89%. Urinary protein qualitative positive group three indicators were significantly higher than the control group, the detection rate reached 100%. Conclusions: Combined detection of morning urine TFU, UMA and IgG is a sensitive and reliable experimental indicator for early diagnosis of SLE kidney damage