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目的:总结脑深部刺激(DBS)治疗帕金森病的并发症和不良反应。方法:自2000 年1 月至2004 年3 月用DBS治疗帕金森病63例,共93侧。手术采用磁共振扫描结合微电极记录技术进行靶点定位。术后随访3 个月至4 年,平均7.3 个月,对其并发症和不良反应进行分析。结果:DBS并发症和不良反应有电极放置不准重新调整2 例,刺激电极与皮下导线连接处头皮切口破溃1例,胸部脉冲发生器植入处皮下感染1例,记忆力轻度减退2 例,情绪改变7 例,肢体异动19 例,睁眼困难1例,但未发生明显的致残性永久并发症和不良反应。结论:DBS是一种微创外科治疗手段,提高手术熟练程度可降低其并发症和不良反应发生率。
Objective: To summarize the complications and adverse reactions of deep brain stimulation (DBS) in the treatment of Parkinson’s disease. Methods: From January 2000 to March 2004, 63 patients with Parkinson’s disease were treated with DBS, a total of 93 sides. Surgery using magnetic resonance scanning combined with microelectrode recording technology for target location. The patients were followed up for 3 months to 4 years with an average of 7.3 months. The complications and adverse reactions were analyzed. Results: DBS complications and adverse reactions were not allowed to readjust the electrode placement in 2 cases, the stimulation electrode and the subcutaneous lead scalp incision ulceration in 1 case, subcutaneous infection in the chest pulse generator implantation in 1 case, mild memory loss in 2 cases , Emotional changes in 7 cases, limbs in 19 cases, 1 case of open eyes difficulties, but no significant permanent disability complications and adverse reactions. Conclusion: DBS is a minimally invasive surgical treatment to improve the proficiency of surgery can reduce the incidence of complications and adverse reactions.