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目的探讨他汀类药物对2型糖尿病(NIDDM)患者凝血功能及血管内皮炎性的影响。方法113例NIDDM患者,其中观察组53例口服辛伐他汀合并阿司匹林。对照组60例仅口服阿司匹林。分别对两组在服用辛伐他汀8周前后采血检测空腹血糖(FPG)、血浆纤维蛋白原(Fg)、D-二聚体(D-di-mer),C-反应蛋白(CRP)、甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL)和低密度脂蛋白胆固醇(LDL)。结果观察组服用辛伐他汀8周后TC,TG,LDL和CRP较服药前均明显降低(P<0.05)。Fg和D-dimer服药前后无显著性差异(P>0.05)。结论他汀类药物能明显改善糖尿病患者血脂胆固醇水平及血管内皮炎性反应,对防治并发症具有临床指导意义。
Objective To investigate the effects of statins on the coagulation function and endothelium-dependent inflammation in type 2 diabetes mellitus (NIDDM). Methods A total of 113 patients with NIDDM were included. Among them, 53 patients in the observation group were given simvastatin and aspirin orally. The control group of 60 patients were given aspirin only. The levels of fasting blood glucose (FPG), plasma fibrinogen (Fg), D-di-mer, C-reactive protein (CRP) Triester (TG), Total Cholesterol (TC), High Density Lipoprotein Cholesterol (HDL) and Low Density Lipoprotein Cholesterol (LDL). Results The levels of TC, TG, LDL and CRP in observation group after taking simvastatin were significantly lower than those before medication (P <0.05). Fg and D-dimer before and after taking no significant difference (P> 0.05). Conclusion Statins can significantly improve the level of serum lipids and endothelium inflammatory reaction in patients with diabetes, which has clinical significance in the prevention and treatment of complications.