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肼苯哒嗪通过直接松弛小动脉平滑肌而使外周循环血管扩张,早期报道它对全身循环的血管扩张作用并不一致。本研究评价慢性严重充血性心衰病人(非冠心病患者)口服肼苯哒嗪后对冠状血管的作用。10例心功能Ⅲ—Ⅳ级的非缺血性充血性心衰病人,男女各5例,平均年龄48(23～58)岁。均经心导管检查证实,并排除贫血、原发性肝功能不全、尿毒症、原发性心瓣膜病和急性心肌炎等疾病。试验前
Hydralazine directly dilates peripheral circulation by relaxing the smooth muscle of arterioles. It was reported earlier that it is not consistent with the vasodilator effect of systemic circulation. This study evaluated the effects of hydralazine on coronary vessels in patients with chronic severe congestive heart failure (non-CHD patients). Ten patients with non-ischemic congestive heart failure with grade Ⅲ-Ⅳ heart function were enrolled in this study. There were 5 males and 5 females, mean age 48 (23-58 years). Cardiac catheterization confirmed by and exclude anemia, primary liver insufficiency, uremia, primary valvular heart disease and acute myocarditis and other diseases. Before the test