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为了研究和开发新的抗偏头痛药物,用电刺激三叉神经节和辣椒素静脉注射刺激的方法造成大鼠硬脑膜内血浆蛋白渗出,建立神经原性炎症动物模型。本实验观察到电刺激三叉神经节增加了刺激侧硬脑膜内125IHSA 的渗出,而非刺激侧125IHSA 的渗出水平未发生明显波动。在刺激后60 min 内,渗出量变化不大。另外观察到抗偏头痛发作药物二氢麦角胺(DHE) 具有减少上述血浆蛋白渗出的作用。
In order to research and develop new anti-migraine drugs, the stimulation of trigeminal ganglion and capsaicin by electrical stimulation resulted in the exudation of plasma proteins in the dura mater of rats, and the animal model of neurogenic inflammation was established. In this experiment, electrical stimulation of the trigeminal ganglion increased the exudation of 125I-HSA in the dural side of the stimulus, whereas the exudative level of 125I-HSA on the non-stimulated side did not fluctuate significantly. Within 60 min after stimulation, exudation changed little. In addition, dihydroergotamine (DHE), an anti-migraine drug, has been observed to reduce the above-mentioned plasma protein exudation.