论文部分内容阅读
肿瘤转移机理是当前肿瘤研究的重要课题之一。尽管现在对癌症的化疗、放疗和手术治疗等比过去有很大进展,但大多数癌症病人仍死于癌症转移。几十年来不少学者试图通过动物试验复制淋巴道癌转移的模型,进行转移机理和防治的研究。Pearce及Brown(1923)最先把Broww-Pearce癌细胞注入兔的睾丸,发现约有40％的动物发生淋巴道转移。以后陆续有不少学者用不同的瘤株,经不同的途径,在不同的动物体内建立了肿瘤的淋巴道转移模型。本文就国外建立肿瘤淋巴道转移模型的主要方法介绍如下:
The mechanism of tumor metastasis is one of the important topics in current tumor research. Although cancer chemotherapy, radiotherapy, and surgical treatment have made great progress in the past, most cancer patients still die from cancer metastasis. For decades, many scholars have tried to copy the model of lymphatic metastasis through animal experiments to study the mechanism of metastasis and prevention. Pearce and Brown (1923) first injected Broww-Pearce cancer cells into rabbit testes and found that about 40% of animals had lymphatic metastases. Since then, many scholars have used different tumor strains to establish lymphatic metastasis models of tumors in different animals in different ways. This article describes the main methods for the establishment of tumor lymphatic metastasis models abroad: