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目的探讨经鼻蝶垂体腺瘤切除术后早期、持续使用麻黄碱滴鼻的方法及效果。方法将179例经鼻蝶垂体腺瘤切除术患者随机分为观察组(89例)和对照组(90例)。两组术后均按照常规鼻腔填塞纱条,对照组摘除纱条后用麻黄碱滴鼻,3次/d,1～2gtt/次,直至鼻腔无血性分泌物停止;观察组在鼻腔填塞纱条期间,即于纱条与鼻翼间隙内滴入麻黄碱,3～7次/d,1～2gtt/次,直至鼻腔无血性分泌物后再持续使用3～5d。结果摘除鼻腔填塞纱条后,观察组鼻腔渗血、鼻塞情况显著低于对照组,切口愈合情况显著优于对照组(P<0.05,P<0.01)。结论经鼻蝶垂体瘤切除术后早期及持续使用麻黄碱滴鼻,可提高创面止血效果,降低术后并发症发生率,促进患者康复。
Objective To investigate the method and effect of continuous intranasal ephedrine nasal drops early after resection of nasal pituitary adenoma. Methods 179 patients with nasal pituitary adenoma resection were randomly divided into observation group (89 cases) and control group (90 cases). The nasal packing gauze and the control group were treated with ephedrine nasal drops 3 times / d, 1 ~ 2gtt / times, until the bloody nasal discharge stopped; the observation group in the nasal packing gauze Ephedrine, 3 to 7 times / d, 1 ~ 2gtt / times, until the nasal bloody discharge and then continued to use 3 ~ 5d. Results After nasal packing gauze was removed, the nasal cavity oozing and nasal obstruction in the observation group were significantly lower than those in the control group. The incision healing was significantly better than the control group (P <0.05, P <0.01). Conclusion Early and continuous ephedrine nasal drops after pituitary adenoma resection can improve the wound hemostatic effect, reduce the incidence of postoperative complications and promote the recovery of patients.