This paper was based on the Hu sheep in China, after collecting the same data about 9 Asiasheep populations and 5 European sheep (breeds in Japan) populations. It clustered 15 populations in terms ofthe gene frequency of 10 loci and 33 allele in blood enzyme and other protein variations. The result of Hierar-chy Clustering showed that the sheep populations in the East and South of Central Asia could be classified intothree genetic groups: Mongolia sheep, South Asia sheep and European sheep, and the Hu sheep belonged toMongolia sheep.