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目的:探讨外周血肿瘤标志物癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片段(CYFRA21-1)、糖链抗原125(CA125)、糖链抗原19-9(CA19-9)、糖链抗原15-3(CA15-3)联合检测在肺癌早期诊断中的应用价值。方法:采用Elecsys2010电化学发光仪检测80例肺癌患者,55例肺部良性疾病患者,40例健康人血清中CEA、NSE、CYFRA21-1、CA125、CA19-9、CA153等肿瘤标志物的水平。结果:肺癌患者中CEA、NSE、CYFRA21-1、CA125、CA19-9、CA153等6种标志物显著高于正常对照组及肺部良性疾病组,差异有统计学意义(P<0.01)。6项标志物不同组合对不同分期肺癌检出的敏感性均高于单项标志物。其中第6种CY-FRA21-1+CA125+NSE和第7种CYFRA21-1+CA125+NSE+CEA组合的敏感性较其他组合均高,特别是对早期患者检出率明显提高,但第7种方式成本较高且6、7两种方式检出率差异无统计学意义。结论:CYFRA21-1+CA125+NSE联合检测能提高肺癌的早期诊断率。
Objective: To investigate the correlation between CEA, NSE, CYFRA21-1, CA125, 19- 9 (CA19-9), sugar chain antigen 15-3 (CA15-3) combined detection of lung cancer in the early diagnosis of the value. Methods: The levels of CEA, NSE, CYFRA21-1, CA125, CA19-9 and CA153 in serum of 80 patients with lung cancer, 55 patients with benign lung disease and 40 healthy controls were detected by Elecsys2010 electrochemiluminescence apparatus. Results: Six markers of CEA, NSE, CYFRA21-1, CA125, CA19-9 and CA153 in lung cancer patients were significantly higher than those in normal control group and benign lung disease group (P <0.01). The sensitivity of different combinations of six markers in detection of lung cancer at different stages were higher than that of single marker. Among them, the combination of the 6th CY-FRA21-1 + CA125 + NSE and the 7th CYFRA21-1 + CA125 + NSE + CEA had higher sensitivity than other combinations, especially the detection rate of early patients was significantly increased. However, There is no significant difference in the detection rate between the two methods in 6 and 7 ways. Conclusion: The combined detection of CYFRA21-1 + CA125 + NSE can improve the early diagnosis rate of lung cancer.