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目的:探讨有高血压家族史但血压正常的青少年血清抵抗素的变化。方法:研究对象为30例有高血压家族史、本人血压正常的青少年(家族史阳性组,FH+组)和30例无高血压家族史、血压正常的青少年(对照组,FH-组),测定其身高、体重、体重指数(BMI)、血压、空腹血糖(FBG)、血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)和血清抵抗素(Resistin)。结果:FH+组青少年的BMI、收缩压、FBG、TC、LDL-C和血清抵抗素均高于FH-组,差异有统计学意义(P<0.05)。血清抵抗素水平与收缩压(SBP)和FBG呈正相关(P<0.05)。结论:有高血压家族史的青少年即使在血压尚处于正常范围时,已发生血清抵抗素水平升高,血清抵抗素水平可能与血压相关。
Objective: To investigate the changes of serum resistin in adolescents with normal family history of hypertension. Methods: The subjects were 30 adolescents (family history positive group, FH + group), 30 family history of hypertension without hypertension and normal blood pressure (control group, FH group) with family history of hypertension, The body weight, body mass index, blood pressure, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL- C) and serum resistin (Resistin). Results: The levels of BMI, systolic blood pressure, FBG, TC, LDL-C and serum resistin in FH + group were higher than those in FH- group, the difference was statistically significant (P <0.05). Serum resistin levels were positively correlated with SBP and FBG (P <0.05). CONCLUSIONS: Adolescents with a family history of hypertension have an increased level of serum resistin, even though blood pressure is still in the normal range, and serum resistin levels may be associated with blood pressure.