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作者对17例严重慢性心衰病人(其中10例缺血性心脏病,7例原发扩张型心肌病)给以口服左旋多巴治疗观察其对全身及神经体液的影响。口服1.5g左旋多巴后最高平均多巴胺水平为19.6±16.4ng/ml。在达到最高多巴胺水平时,心脏指数增加14%(P<0.05)、每搏输出指数增加14%(P<0.01)周围血管阻力降低13%(P=0.08)。而心率、动脉平均压、右房压、肺毛细血管楔压,肺血管阻力以及心率压力乘积没有明显改变。另
The author of 17 cases of severe chronic heart failure patients (10 cases of ischemic heart disease, 7 cases of primary dilated cardiomyopathy) given oral levodopa treatment of its systemic and neurohumoral effects. The highest average dopamine level after oral administration of 1.5 g levodopa was 19.6 ± 16.4 ng / ml. Cardiac index increased by 14% (P <0.05) and stroke volume index increased by 14% (P <0.01) by 13% (P = 0.08) at the highest dopamine level. The heart rate, mean arterial pressure, right atrial pressure, pulmonary capillary wedge pressure, pulmonary vascular resistance and heart rate pressure product did not change significantly. another