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采用比色法测定２００名不同疾病患者血清中鸟嘌呤脱氨酶（ＧＤ）活性，发现除肝脏疾病患者血清中ＧＤ活性高于正常外，其它疾病患者的ＧＤ活性均不升高。不同类型的肝脏疾病中，急性肝炎患者ＧＤ活性比慢性肝炎高，急慢性肝炎、肝内外胆道梗阻患者血清ＧＤ活性与丙氨酸氨基转移酶呈直线正相关；在慢性活动性肝炎、肝内外胆道梗阻、肝硬化时患者血清ＧＤ活性与总胆红素浓度呈直线正相关；抗ＨＣＶ阳性患者ＧＤ活性也显著升高。由此表明，血清ＧＤ检测是反映肝脏功能的一项特异、灵敏的指标，并有助于对急慢性肝炎、肝硬化的鉴别诊断及对丙型肝炎的诊断。
The colorimetric method was used to measure the activity of guanine deaminase (GD) in serum of 200 patients with different diseases. The activity of GD in the serum of patients with liver diseases was higher than that in normal subjects. The activity of GD in other diseases did not increase. In different types of liver diseases, GD activity in patients with acute hepatitis is higher than chronic hepatitis, acute and chronic hepatitis, serum bcl-2 activity and alanine aminotransferase in patients with intrahepatic or extrahepatic biliary obstruction have a linear positive correlation; chronic active hepatitis, Obstruction, liver cirrhosis patients with serum GD activity and total bilirubin concentration was a linear positive correlation; anti-HCV-positive patients with GD activity was significantly increased. Thus, serum GD detection is a specific and sensitive indicator of liver function and contributes to the differential diagnosis of acute and chronic hepatitis, cirrhosis and diagnosis of hepatitis C.