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目的建立稳定的、符合生理的门静脉回流、空肠内引流术式猪全胰十二指肠移植模型。方法40头四川本地杂种猪分为供、受体两组(n=20)。采用UW液低温灌注的方法,整块切取供体全胰十二指肠,保留腹主动脉Carrel片和门静脉。UW液保存、修整后的胰腺十二指肠移植物用髂血管延长的动脉与供体腹主动脉段端-侧吻合;门静脉与供体肠系膜上静脉端-侧吻合;十二指肠与供体空肠侧-侧吻合。结果共完成猪全胰十二指肠移植手术20例。胰腺移植术后1例因麻醉过深,呼吸抑制而术后未能复苏;1例移植胰腺血栓形成、血管栓塞;另1例死于肠瘘导致的腹腔感染。17例术后第2天检测外周血血糖正常。结论猪全胰十二指肠移植门静脉回流、空肠内引流术式大动物模型稳定、可靠。
Objective To establish a stable and physiologically-compatible model of porcine pancreaticoduodenal transplantation with portal venous return and jejunal drainage. Methods Forty heads of local hybrid pigs in Sichuan were divided into donor and recipient groups (n = 20). UW solution by low-temperature perfusion method, the whole piece of the donor pancreas duodenum, retaining the abdominal aorta Carrel films and portal vein. UW fluid preservation, repair of pancreatic duodenal grafts iliac vessels with the extension of the arteries and donor abdominal aorta end-side anastomosis; portal vein and the donor mesenteric vein end-side anastomosis; duodenum and for Jejunal side - side anastomosis. Results A total of 20 cases of pan pancreaticoduodenectomy were completed. One case of pancreas transplantation due to too deep anesthesia, respiratory depression and failed to recover after surgery; 1 case of pancreas thrombosis, vascular embolism; the other died of intestinal fistula caused by abdominal infection. 17 cases of the second day after surgery to detect peripheral blood glucose. Conclusions Total pancreateral pancreaticoduodenectomy portal vein reflux, jejunal drainage of large animal models of stable and reliable.