“523”是一种辐射防护剂,并可用于更年期综合征的治疗。鉴于人员用药时间较长,根据国家药政管理法的要求,我们进行了致突变实验研究。6名正常人外周血淋巴细胞培养物加入不同浓度的“523”后,分析计数了染色单体型、染色体型畸变及姊妹染色单体交换(SCE)。实验结果说明,“523“诱发的细胞遗传学变化,虽然略高于正常对照水平,但低于溶剂(酒精)对照。本文的结论是,“523”实验组观察到的变化,主要是酒精的作用,而“523”本身并没有可检查到的致突变效应。 “523” is a radioprotectant and can be used for the treatment of menopausal syndrome. Given the longer duration of medication, we conducted a mutagenic experimental study in accordance with the requirements of the National Drug Administration Law. Six normal human peripheral blood lymphocyte cultures were analyzed for chromosomal aberrations, chromosomal aberrations and sister chromatid exchange (SCE) after addition of different concentrations of “523”. The experimental results show that “523” induced cytogenetic changes, although slightly higher than the normal control level, but lower than the solvent (alcohol) control. The conclusion of this paper is that the observed changes in the “523” experimental group are predominantly alcoholic, whereas “523” itself does not have detectable mutagenic effects.