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目的介绍高通量筛选技术(high throughput screening,HTS)在中药研究领域中的应用及表现出的优势。方法从中药化学成分的研究、中药有效部位的研究和中药复方的研究三个方面论述在目前条件下,高通量筛选技术在中药研究领域中的应用及表现出的优势。结果与结论高通量筛选技术是中药研究的主要手段之一,是现代药学研究的重要工具之一。高通量筛选在中药研究方面也是符合实际而且可行的工作。1.对中药成分进行大规模的生物活性筛选,可以对中药成分进行更广泛的研究和认识;2.在分子、细胞水平认识中药的作用和机理;3.充分挖掘和利用宝贵中药资源,开发新型药物。可以预见,经过高通量筛选对中药多方面生物活性的研究,定将对中药的发展起到促进作用。
Objective To introduce the application and advantages of high throughput screening (HTS) in the field of traditional Chinese medicine. Methods The application of high-throughput screening in the field of traditional Chinese medicine (TCM) and its advantages are discussed under the current conditions from three aspects: the study of chemical components of traditional Chinese medicine, the study of effective parts of traditional Chinese medicine and the study of traditional Chinese medicine. RESULTS AND CONCLUSION High-throughput screening is one of the main means of TCM research and one of the important tools in modern pharmaceutical research. High-throughput screening in the study of traditional Chinese medicine is also realistic and feasible work. 1. To conduct a large-scale biological activity screening of traditional Chinese medicine components, to make more extensive research and understanding of traditional Chinese medicine components; 2. To understand the function and mechanism of traditional Chinese medicine at the molecular and cellular level; 3. To fully exploit and utilize valuable traditional Chinese medicine resources and to develop New drug It is foreseeable that after high-throughput screening of many aspects of biological activity of traditional Chinese medicine, will play a catalytic role in the development of Chinese medicine.