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目的探讨血浆同半胱氨酸(Homocysteine,Hcy)水平与脑卒中之间的关系。方法选择脑卒中患者60例作为研究组,其中缺血性脑卒中50例,出血性脑卒中10例。对照组为40例健康人。采用荧光偏振免疫分析法测定血浆Hcy。检测健康人与脑卒中患者的血浆Hcy水平,统计高Hcy卒中患者与正常Hcy卒中患者伴随的脑卒中危险因素状况,并进行对比分析。结果脑卒中Hcy水平(26.56±6.38)μmol/L,对照组(9.15±2.30)μmol/L,差异有统计学意义(P<0.05);脑卒中组高Hcy血症发生率41%,对照组5%,差异有统计学意义(P<0.01)。高Hcy卒中患者与正常Hcy卒中患者伴随的吸烟、高血压症、糖尿病及高血脂症的状况差异无统计学意义(χ2=0.39,0.09,0.48,1.06,P>0.05)。结论 Hcy与脑卒中密切相关,高Hcy血症是脑卒中的独立危险因素。
Objective To investigate the relationship between plasma homocysteine (Hcy) level and stroke. Methods Sixty patients with stroke were selected as the research group, including 50 ischemic stroke and 10 hemorrhagic stroke. The control group was 40 healthy people. Plasma Hcy was measured by fluorescence polarization immunoassay. The plasma Hcy level in healthy and stroke patients was detected. The risk factors of stroke associated with Hcy stroke patients and normal Hcy stroke patients were calculated and compared. Results The level of Hcy in stroke group was (26.56 ± 6.38) μmol / L and in control group (9.15 ± 2.30) μmol / L, the difference was statistically significant (P <0.05) 5%, the difference was statistically significant (P <0.01). There was no significant difference in the prevalence of smoking, hypertension, diabetes and hyperlipidemia among high Hcy stroke patients and normal Hcy stroke patients (χ2 = 0.39,0.09,0.48,1.06, P> 0.05). Conclusions Hcy is closely related to stroke, and high Hcy is an independent risk factor for stroke.