本文介绍一种可有效地测定氯氮艹卓 含量的方法。在pH =4 .0的HAc NaAc缓冲溶液中 ,加入过量的四苯硼钠与氯氮艹卓反应可形成分子比为 1∶1的定量沉淀 ,过滤 ,弃去初滤液。以溴酚蓝为指示剂 ,用十六烷基三甲基溴化铵标准溶液滴定续滤液中过量的四苯硼钠 ,方法简便 快速 ,应用于多批氯氮艹卓 原料药样品的测定 ,其回收率为 99.5 8%～ 10 0 .4 % ,相对误差<± 0 .5 0 % ,与中国药典法测得的结果基本一致 This article describes a method for the efficient determination of clozaphene content. In pH = 4.0 HAc NaAc buffer solution, an excess of sodium tetraphenylborate was added to react with chlordiazepoxide to give a quantitative precipitate with a molecular ratio of 1: 1. The initial filtrate was filtered and discarded. Using bromophenol blue as an indicator, the excess sodium tetraphenylborate in the filtrate was titrated with cetyltrimethylammonium bromide standard solution, the method was rapid and convenient, and was applied to the determination of batch samples of clozaprazine, The recoveries were 99.5 8% ~ 100.4%, the relative errors were less than ± 0.5%, which was consistent with the results of Chinese Pharmacopoeia