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目的探讨早发型与晚发型重度子痫前期临床特点及围产儿结局。方法选取江门市南方医科大学附属新会医院2012年5月-2016年3月收治的重度子痫前期患者122例为研究对象,根据发病时间分为早发型组(发病时间<34周孕)75例,晚发型组(发病时间≥34周孕)47例,对两组患者临床资料及生化指标进行分析,并记录围产儿结局。结果早发型组患者治疗时间、系统产检率、分娩时间、发病时间、收缩压、舒张压等指标与晚发型组比较,差异均有统计学意义(P<0.05);早发型组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)明显较晚发型组短,D-二聚体(DD)、血小板计数(PLT)较晚发型组低,尿蛋白与纤维蛋白原(Fg)较晚发型组高,差异均有统计学意义(P<0.05);结论早发型重度子痫前期患者的血液高凝状态严重,会直接影响围产儿结局。
Objective To investigate the clinical features of early-onset and late-onset severe preeclampsia and the outcomes of perinatal infants. Methods A total of 122 patients with severe preeclampsia who were admitted to Xinhui Hospital affiliated to Southern Medical University from May 2012 to March 2016 were enrolled in this study. They were divided into early-onset group (onset time <34 weeks) 75 according to the onset time. Cases, late-onset group (onset time ≥ 34 weeks pregnant) 47 cases of clinical data and biochemical indicators of two groups were analyzed and the outcome of perinatal records. Results Compared with the late-onset group, the indexes of early-onset group, such as the treatment time, the rate of childbirth, the onset time, the systolic blood pressure and the diastolic blood pressure, were significantly different (P <0.05) (PT) and APTT were significantly lower in the late-onset group, DD and PLT than in the late-onset group, and higher in the urine protein and fibrinogen (Fg) (P <0.05). CONCLUSIONS: Serious hypercoagulability in patients with early-onset severe preeclampsia directly affects perinatal outcomes.