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长期以来人们认为肝纤维化是不可逆转的,也无特殊抗纤维化药物。1973年以来Rojkind等陆续报告秋水仙碱治疗肝硬化有效,于是人们开始秋水仙碱治疗肝纤维化的研究。羟脯氨酸(HYP)是人体胶原蛋白特有的氨基酸,体内血、尿HYP含量的变化可反映体内胶原代谢情况。我们观察晚期血虫吸病(晚血)患者接受秋水仙碱治疗后的血、尿HYP含量变化,以探讨其疗效机制。 我们测定了20名来自重流行区,多次接受血吸虫病治疗的晚血患者血游离HYP量和尿游离和
For a long time, people think that liver fibrosis is irreversible, nor is there any special antifibrotic drug. Since 1973, Rojkind and other reports of colchicine treatment of liver cirrhosis is effective, so people began to colchicine treatment of liver fibrosis research. Hydroxyproline (HYP) is a unique amino acid of human collagen. The change of HYP content in blood and urine in vivo reflects the collagen metabolism in vivo. We observed the late blood worm infection (late blood) patients receiving colchicine blood and urine levels of HYP to explore its mechanism of action. We measured 20 from the heavy endemic areas, many patients receiving schistosomiasis treatment of blood free HYP amount of blood and urine free and