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用D－氨基半乳糖（D－GalN）制备大鼠急性肝损伤模型。通过检测血清丙氨酸转氨酶活性（ALT）、肿瘤坏死因子－α（TNF－α）浓度，并观察光镜和电镜下肝组织的病理学改变，以探讨中药肝炎平对急性肝损害的保护作用。结果发现：肝损伤组ALT活性和TNF－α浓度分别为（2442．16±445．09）nmol·s（-1）／L见和（8．07±1．93）μg／L，而肝炎平组则为（1258．59±468．43）nmol·s（-1）／L和（0.63±0．27）μg／L。肝炎平可显著降低血清ALT和TNF－α的水平，减轻肝细胞的变性坏死，其对肝细胞的保护作用与肝得健一致。
Rat acute liver injury model was prepared with D-galactosamine (D-GalN). The serum alanine aminotransferase (ALT) and tumor necrosis factor-α (TNF-α) concentrations were measured, and the pathological changes of liver tissue were observed under light microscope and electron microscope to explore the protective effect of Heyan-ping on acute liver damage. . The results showed that the ALT activity and TNF-α concentration in the liver injury group were (2442.16±445.09) nmol·s(-1)/L and (8.07±1.93) μg/L, respectively, while the hepatitis was observed. In the plain group, it was (1258.59±468.43) nmol·s(-1)/L and (0.63±0.27) μg/L. Hepatitis can significantly reduce the level of serum ALT and TNF-α, reduce the degeneration and necrosis of hepatocytes, and its protective effect on hepatocytes is consistent with that of liver.