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目的:探讨与乳腺癌保乳术后局部复发相关的因素。方法:回顾性分析2000年1月—2007年12月接受保乳手术的548例乳腺癌患者的病历资料并进行随访。对与乳腺癌保乳术后局部复发相关的因素进行单因素和多因素分析。结果:548例患者中,局部复发22例(4.01%)。年龄(<45岁和≥45岁,P=0.041)、肿瘤大小(T1、T2和T3,P=0.014)和组织学分级(Ⅰ～Ⅱ级和Ⅲ级,P=0.003)与局部复发相关。多因素分析结果显示,年龄(<45岁和≥45岁,P=0.013)和组织学分级(Ⅰ～Ⅱ级和Ⅲ级,P=0.046)是影响乳腺癌保乳术后局部复发的独立因素。结论:青年乳腺癌患者(<45岁)保乳术后具有相对较高的局部复发风险,临床医师应当采取更为积极的治疗措施以预防局部复发。
Objective: To explore the factors associated with local recurrence after breast-conserving surgery. Methods: The clinical data of 548 breast cancer patients undergoing breast-conserving surgery from January 2000 to December 2007 were retrospectively analyzed and followed up. Univariate and multivariate analyzes were performed on the factors associated with local recurrence after breast-conserving surgery. Results: Among 548 patients, 22 cases (4.01%) had local recurrence. Tumor size (T1, T2 and T3, P = 0.014) and histological grade (grade Ⅰ ~ Ⅱ and grade Ⅲ, P = 0.003) were associated with local recurrence at age (45 years and ≥45 years, P = 0.041). Multivariate analysis showed that age (45 years old and ≥45 years old, P = 0.013) and histological grade Ⅰ ~ Ⅱ and Ⅲ (P = 0.046) were the independent factors affecting the local recurrence after breast conserving surgery . CONCLUSIONS: Young breast cancer patients (<45 years old) have a relatively high risk of local recurrence after breast-conserving surgery, and clinicians should adopt more aggressive treatment to prevent local recurrence.