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目的评价PET/CT双时相显像对胰腺良恶性病变鉴别诊断的应用价值。方法对81例胰腺恶性病变和41例胰腺良性病变行18F-FDG PET/CT常规显像,其中46例胰腺恶性病变和22例胰腺良性病变行PET/CT延迟显像。寻求早期最大标准摄取值(SUV早期)和滞留指数(RI)的最佳诊断界值。结果胰腺恶性病变组SUV早期(5.46±3.51)明显高于良性病变组SUV早期(1.89±1.28)(P<0.05),胰腺恶性病变组SUV延迟(5.87±3.79)高于良性病变组SUV延迟(2.64±1.94)(P<0.05)。其中68例行PET/CT双时相显像的胰腺病变患者中,胰腺良性病变组SUV早期(2.33±1.25)和SUV延迟(2.64±1.94)差异无统计学意义(P>0.05);胰腺恶性病变组SUV早期(4.52±2.98)和SUV延迟(5.87±3.79)差异有统计学意义(P<0.05)。根据ROC曲线,以SUV早期=2.75为本研究的最佳诊断界值,灵敏度、特异度和准确度分别为82.72%、80.49%和81.97%;以RI%=12.04%为界值,灵敏度、特异度和准确度分别为82.61%、72.72%和79.41%;以SUV早期=2.75和RI%=12.04%为联合诊断标准,灵敏度、特异度和准确度分别为93.48%、59.10%和82.35%。结论18F-FDG PET/CT双时相显像对胰腺良恶性病变有良好的鉴别诊断价值。
Objective To evaluate the value of dual-phase PET / CT in the differential diagnosis of benign and malignant pancreatic lesions. Methods 18F-FDG PET / CT conventional imaging was performed on 81 cases of pancreatic malignant lesions and 41 cases of benign pancreatic lesions. 46 cases of pancreatic malignant lesions and 22 cases of benign pancreatic lesions underwent PET / CT delayed imaging. Seek the best diagnostic cutoff for early maximal standard uptake (early SUV) and retention index (RI). Results The severity of SUV in the pancreatic malignant group was significantly higher than that in the benign group (5.46 ± 3.51 vs 1.89 ± 1.28, P <0.05). The SUV latency was significantly lower in the pancreatic malignant group (5.87 ± 3.79) than in the benign group 2.64 ± 1.94) (P <0.05). Among the 68 patients with pancreatic lesions undergoing PET / CT bi-phase imaging, there was no significant difference in the early stage of SUV (2.33 ± 1.25) and SUV delay (2.64 ± 1.94) between benign and malignant pancreatic lesions (P> 0.05) There were significant differences in SUV SUV (4.52 ± 2.98) and SUV delay (5.87 ± 3.79) between the two groups (P <0.05). According to the ROC curve, the best diagnostic cutoff value, sensitivity, specificity and accuracy were 82.72%, 80.49% and 81.97% respectively for the early SUV = 2.75; the sensitivity, specificity Sensitivity, specificity and accuracy were 93.48%, 59.10% and 82.35% respectively in the combined diagnosis of early SUV = 2.75 and RI% = 12.04% for the combined diagnosis of 82.61%, 72.72% and 79.41% respectively. Conclusion 18F-FDG PET / CT dual-phase imaging has good differential diagnosis of benign and malignant pancreatic lesions.