目的观察血管紧张素Ⅱ(AngⅡ)对维持性血液透析患者心脑血管透析并发症及死亡率的影响。方法对29例已进入维持透析的走透患者采透前空腹静脉血1ml加入检验科预先制备好的采血管中,摇匀、4℃冷藏,集够5个送检验科用放射免疫分析法进行检测。结果29例走透患者中2例AngⅡ低于正常,11例AngⅡ在正常范围,16例AngⅡ超过正常范围,对29例患者进行随访观察39～44个月,AngⅡ低于正常组2例死于癌症广泛转移,AngⅡ正常组发生急性左心衰竭3次,心律失常13次,脑血栓2例,死于脑出血2例,AngⅡ增高组发生急性左心衰竭8次,心律失常14次,眼底出血3例,死于脑出血1例。结论AngⅡ增高心力衰竭的发作次数明显增多,但并不增加脑血管病的发病率,也不增加透析患者的死亡率。 Objective To observe the effect of Ang Ⅱ on the complication of cardiovascular and cerebrovascular complications and mortality in maintenance hemodialysis patients. Methods Twenty-nine patients who had penetrated into the dialysis maintenance department before operation were enrolled in the pre-prepared blood collection tube and shaken at 4 ℃. Five samples were sent to the laboratory for analysis by radioimmunoassay Detection. Results In 2 of 29 patients, AngⅡ was lower than normal, 11 of them were in normal range and 16 of Ang Ⅱ were beyond the normal range. Twenty-nine patients were followed up for 39-44 months. AngⅡ was lower than that of normal group Extensive cancer metastasis, acute left ventricular failure in Ang Ⅱ normal group three times, 13 cases of arrhythmia, cerebral thrombosis in 2 cases, died of cerebral hemorrhage in 2 cases, Ang Ⅱ increased group acute left ventricular failure occurred 8 times, arrhythmia 14 times, fundus hemorrhage 3 cases died of cerebral hemorrhage in 1 case. Conclusions Ang Ⅱ increased heart failure episodes significantly increased, but did not increase the incidence of cerebrovascular disease, nor increase the mortality of dialysis patients.