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目的:为指导临床合理用药、实现个体化给药提供参考。方法:本文从CYP2C9的基因多态性与代谢表型、代谢底物、代谢酶的诱导和抑制等方面,探讨CYP2C9基因多态性与药物相互作用的关系。结果与结论:CYP2C9作为一种重要的P450系氧化代谢酶,具有基因多态性,参与多种药物的氧化代谢,能被多种药物竞争性抑制,这是造成药物作用个体差异的最重要因素之一,也是发生药物相互作用的原因之一。因此对其研究具有非常重要的临床意义。
Objective: To provide guidance for clinical rational drug use and individualized administration. Methods: The CYP2C9 gene polymorphisms and metabolic phenotype, metabolic substrates, metabolic enzymes induction and inhibition, CYP2C9 gene polymorphism and drug interactions. RESULTS AND CONCLUSION: CYP2C9, as an important P450 oxidative metabolic enzyme, has genetic polymorphism and is involved in the oxidative metabolism of many drugs. It can be competitively inhibited by many drugs, which is the most important factor causing individual differences in drug effects One of the reasons for the drug interaction is also one of the reasons. Therefore, its research has very important clinical significance.