论文部分内容阅读
目的低钾周期性麻痹作为一种常见的并发症,好发于甲状腺毒症的亚洲男子。造成低血钾症和肌麻痹的原因是钾离子突然的细胞内移,而非机体内钾的不足。伴有低钾周期性麻痹的甲状腺毒症患者的临床特点可能是不典型的,不易被临床医生识别。甲状腺毒性低钾周期性麻痹(TPP)的遗传易感性并不完全清楚,编码L型α1钙通道亚基(Cav1.1)的基因CACNA1S多态性与TPP相关已被注意到。本文旨在探讨TPP的临床表现,以及其发病与钙离子通道及CACNA1S基因多态性关系的研究进展。
Objectives Hypokalemic periodic paralysis is a common complication in Asian men with thyrotoxicosis. The cause of hypokalemia and muscle paralysis is the sudden intracellular shift of potassium ions, not the lack of potassium in the body. The clinical features of patients with thyrotoxicosis associated with hypokalemic periodic paralysis may not be typical and not easily recognized by clinicians. Genetic susceptibility to thyrotoxic hypokalemic periodic paralysis (TPP) is not fully understood, and the association of the CACNA1S polymorphism of the gene encoding the L-type α1 calcium channel subunit (Cav1.1) with TPP has been noticed. This article aims to explore the clinical manifestations of TPP, and its incidence and calcium ion channels and CACNA1S gene polymorphism research progress.