论文部分内容阅读
作为高效能的中枢神经抑制剂,γ-羟基丁酸(GHB)其相关物质γ-丁内酯(GBL)和1,4-丁二醇(1,4-BD)的滥用现象越来越严重,由于它们强烈的镇静及健忘效果常常被用作迷奸药,带来了严重的社会问题。由于在体内天然存在GHB,而且其在摄入后消除迅速,这增加了体内GHB及其相关物质的检测和分析评价难度。本文在对GHB及其相关物质的理化性质阐述基础上,综述了它们的提取技术及分析方法研究进展,主要阐述了液-液提取、固相萃取等提取方法与气相色谱法、气相色谱-质谱联用法、高效液相色谱法、液相色谱-质谱联用法、毛细管电泳法等在分析不同检材中GHB及其相关物质的应用,这也为国内法庭案件中GHB及其相关物质的滥用及相关案件提供了可供参考的法庭科学检测、分析研究方法。
As a highly effective central nervous system inhibitor, the abuse of gamma-hydroxybutyrate (GHB) -based substances, γ-butyrolactone (GBL) and 1,4-butanediol , Have been linked to serious social problems because of their strong sedative and forgetfulness effects, which are often used as drug addicts. Due to the natural presence of GHB in the body, and its rapid elimination after ingestion, it increases the difficulty of detection and analysis of GHB and its related substances in vivo. In this paper, based on the physical and chemical properties of GHB and its related substances, the research progress of their extraction technology and analytical methods are summarized. The extraction methods of liquid-liquid extraction, solid-phase extraction, gas chromatography, gas chromatography-mass spectrometry Combined use of high performance liquid chromatography, liquid chromatography - mass spectrometry, capillary electrophoresis, etc. in the analysis of different samples of GHB and its related substances, which is also for the abuse of GHB and related substances in domestic court cases and Related cases provide a forensic scientific test, analysis of research methods.