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目的：探讨清开灵注射液对急性发热的量效及证效关系与不良反应情况观察分析。方法：选择我院2011年1月至2014年1月收治的220例急性上呼吸道感染患者为研究对象，随机分为对照组55例，观察组分为清开灵120、160、200ml 等三个剂量组，每组55例，对照组以洁霉素治疗，对两组患者治疗情况进行分析。结果：观察组治疗总有效率为90．91％，对照组为69．09％，观察组显著优于对照组，差异有统计学意义（P ＜0．05）；清开灵注射液治疗肺胃热盛型的显效率为74．44％。心肺热盛型显效率为90．63％。差异显著（P ＜0．05）。清开灵120ml 治疗效果显著优于其他剂量组及对照组（P ＜0．05）；清开灵注射液使用后，不良反应主要表现为荨麻疹、血管疼痛、寒战高热。结论：清开灵注射液在急性上呼吸道感染的临床治疗中，效果显著，安全性高，使用最佳剂量为每日120ml，值得临床进一步推广使用。“,”Objective:To investigate the relations and adverse reaction between dose and permit of Qing KaiLing injection in treating acute fever.Methods:Selected 220 cases of acute upper respiratory tract infection patients from our hospital from January 2011 -January 2014 as study objects and randomly divided them into observation group(165 cases)and control group(55 cases).Then the observation group was divided into (120ml,160ml and 200ml)three dose groups(120ml,160ml and 200ml)according to the dose of Qing Kai Ling,each dose group with 55 cases.The control group was treated by lincomycin.Then analyze the two groups treatment ef icacy.Results:The observation group’s total ef iciency was 90.91% which was significantly higher than the control group whose total ef iciency was 69.09%.The dif erence between them has statistic significant(P <0.05).The appeared ef iciency of Qing Kailing on heat type lung and stom-ach was 74.44% and on heat type cardiopulmonary was 90.63%.The dif erence was significant(P <0.05).The treatment ef iciency of 120ml Qing Kainling was significant bet er than the other dose group(P <0.05).The main adverse reactions were urticaria,vascular pain,chil s and fever.Conclusion:Qing Kailing injection has significant ef ect and high safety in clinical treatment of acute respiratory tract infection,its optimal dose is 120ml a day,which should be widely applied in clinic.