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目的:探讨肝癌组织中低氧诱导因子-lα(HIF-lα)表达与肝癌行肝移植治疗后肿瘤复发与转移之间的关系。方法:选择肝癌行全肝移植患者45例,应用免疫组化方法检测其切除的肝癌组织、癌旁组织中HIF-lα的表达,分析其表达与移植后肝癌复发与转移之间的关系和意义。结果:肝癌组织中HIF-1α阳性表达率明显高于癌旁组织(X2=6.39,P<0.01)。HIF-1α在肝癌组织中的表达与肿瘤直径、TNM分期、有无淋巴结转移、有无门静脉癌栓及肿瘤播散灶密切相关(P<0.01)。复发转移组和未复发转移组HIF-1α阳性表达率比较,差异存在显著性(X2=8.46,P<0.01)。Cox回归多因素分析表明HIF-1α高表达是影响肝癌患者肝移植后肿瘤复发和转移的独立预后因素(P<0.01)。结论:HIF-1α蛋白有望成为一个预测肝癌患者肝移植后复发和转移的重要指标。
Objective: To investigate the relationship between the expression of hypoxia inducible factor-1α (HIF-1α) and the recurrence and metastasis of hepatocellular carcinoma after liver transplantation. Methods: Forty-five patients with hepatocellular carcinoma who underwent total liver transplantation were selected. The expression of HIF-1alpha was detected by immunohistochemistry in HCC tissues and adjacent tissues. The relationship between the expression of HIF-1alpha and the recurrence and metastasis of hepatocellular carcinoma after transplantation was analyzed . Results: The positive rate of HIF-1α in HCC tissues was significantly higher than that in adjacent tissues (X2 = 6.39, P <0.01). The expression of HIF-1α in hepatocellular carcinoma was closely related to tumor diameter, TNM stage, lymph node metastasis, presence or absence of portal vein tumor thrombus and disseminated tumor (P <0.01). The positive rate of HIF-1α in recurrence group and non-recurrence group was significantly higher than that in non-recurrence group (X2 = 8.46, P <0.01). Cox regression multivariate analysis showed that high expression of HIF-1α was an independent prognostic factor for the recurrence and metastasis of liver cancer patients after liver transplantation (P <0.01). Conclusion: HIF-1α protein is expected to become an important index for predicting the recurrence and metastasis of liver cancer patients after liver transplantation.