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硒蛋白是人和动物必需微量元素硒的主要功能表现形式,硒蛋白P(Selenoprotein P,SEPP)是其中比较特殊的一种,近年来对硒蛋白P的研究越来越多,尤其是硒蛋白P基因多态性与疾病的关系也日益受到关注。鉴于硒蛋白P基因多态性对疾病易感性的意义,本文从硒蛋白P的分子生物学特点、生物功能以及基因多态性与疾病关系的研究进展进行综述,以期为缺硒性地方病的研究开拓新的思路。
Selenoprotein is the main functional manifestation of human and animal essential selenium. Selenoprotein P (SEPP) is a special kind of selenoprotein P. In recent years, there are more and more researches on selenoprotein P, especially selenoprotein The relationship between P gene polymorphism and diseases is also receiving more and more attention. In view of the significance of selenoprotein P gene polymorphism to disease susceptibility, this article reviews the molecular biological features, biological functions, and genetic polymorphisms of selenoprotein P and the relationship between the genetic polymorphisms and diseases, with a view to the study of selenium deficiency endemic diseases Open up new ideas.