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目的:观察奥沙利铂联合化疗治疗晚期大肠癌的临床疗效。方法:33例晚期大肠癌患者,用奥沙利铂(Oxaliplatin,L-OHP由法国赛诺菲公司生产,商品名为乐沙定Eloxatin)130mg/m2,静脉滴注2小时;甲酰四氢叶酸(CF)200mg/m2,静脉滴注2小时;5-氟脲嘧啶(5-FU)0.5g在CF滴完后静推,然后5-FU3.0g/m2用一次性便携式静脉输液器持续静脉滴注48小时,每3周重复1次,治疗2周期后评定疗效,有效病例在4周后确认疗效。结果:33例中CR3例,PR13例,SD13例,PD4例,总有效率(CR+PR)48.5%。毒副作用主要是Ⅰ～Ⅱ度恶心呕吐、腹泻、感觉神经毒性、粘膜炎、骨髓抑制、静脉炎等。结论:奥沙利铂联合5-FU+CF治疗晚期大肠癌效果良好,不良反应能耐受,值得临床推广使用。
Objective: To observe the clinical efficacy of oxaliplatin plus chemotherapy in the treatment of advanced colorectal cancer. Methods: Thirty-three patients with advanced colorectal cancer were treated with oxaliplatin (L-OHP, 130 mg / m2, manufactured by French Sanofi Co., Ltd. under the trade name of Eloxatin) for 2 hours. Folic acid (CF) 200mg / m2, intravenous infusion for 2 hours; 5-fluorouracil (5-FU) 0.5g after CF drip static push, then 5-FU3.0g / m2 with a disposable portable intravenous infusion continued Intravenous infusion of 48 hours, repeated once every 3 weeks, 2 weeks after treatment to assess the efficacy of effective cases in 4 weeks to confirm the efficacy. Results: 33 cases of CR3 cases, PR13 cases, SD13 cases, PD4 cases, the total effective rate (CR + PR) 48.5%. Side effects are mainly Ⅰ ~ Ⅱ degree of nausea and vomiting, diarrhea, sensory neurotoxicity, mucositis, bone marrow suppression, phlebitis and so on. Conclusion: Oxaliplatin combined with 5-FU + CF is effective in treating advanced colorectal cancer and its adverse reactions are tolerable, which is worthy of clinical application.