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目的探讨沙丁胺醇联合布地奈德治疗支气管哮喘急性发作患者的临床疗效。方法选取2015年8月至2016年8月揭西县妇幼保健院收治的支气管哮喘急性发作患者80例,随机分为A组和B组,各40例。B组患者采用沙丁胺醇治疗,A组患者在B组治疗基础上采用布地奈德治疗。比较A、B两组患者治疗后的总有效率、肺功能、不良反应发生率以及生命质量评分。结果 A组患者治疗的总有效率明显高于B组,差异有统计学意义(P<0.05);经过7 d的治疗,A组患者的用力肺活量(FVC)、第一秒用力呼气量(FEV1)和最大通气量(MVV)均明显高于B组,差异均有统计学意义(均P<0.05);A组患者物质生活、心理功能、社会功能以及躯体功能评分均明显高于B组,差异均有统计学意义(均P<0.05)。结论沙丁胺醇、布地奈德联合治疗支气管哮喘急性发作临床效果显著,可有效改善患者肺功能,提升生命质量,并且不良反应发生率极低。
Objective To investigate the clinical efficacy of salbutamol combined with budesonide in the treatment of patients with acute exacerbation of bronchial asthma. Methods Eighty patients with acute exacerbation of bronchial asthma admitted to MCH from August 2015 to August 2016 were randomly divided into A group and B group, 40 cases in each group. Patients in group B were treated with albuterol, and patients in group A were treated with budesonide on the basis of group B treatment. The total effective rate, lung function, incidence of adverse reactions and quality of life scores of patients in group A and group B after treatment were compared. Results The total effective rate of treatment in group A was significantly higher than that in group B, the difference was statistically significant (P <0.05). After 7 days of treatment, the group of patients with forced vital capacity (FVC), forced expiratory volume one second FEV1 and MVV were significantly higher than those in group B (all P <0.05). The scores of physical, psychological, social and physical function in group A were significantly higher than those in group B , The differences were statistically significant (all P <0.05). Conclusion Salbutamol and budesonide are effective in treating acute exacerbation of bronchial asthma, which can effectively improve lung function and quality of life of patients, and the incidence of adverse reactions is very low.