论文部分内容阅读
药物性肝损伤是指在治疗过程中,由于药物的毒性损害或过敏反应所致的肝脏疾病,也称药物性肝炎[1]。药物性肝损伤分为两大类:中毒性肝损伤和特异质性肝损伤。前者是药物或其代谢产物直接损害肝脏,与药物剂量有关,具有可预测性。代表药物为对乙酰氨基酚,其潜伏期短,可以复制出动物模型。病理特点为肝小叶特定部位的肝细胞坏死。后者为药物半抗原与肝细胞中特异蛋白质结合成为抗原,抗原经抗原呈递细胞加工激活免疫系统,导致肝损
Drug-induced liver injury refers to the treatment process, due to the toxicity of drugs or allergic reactions caused by liver disease, also known as drug-induced hepatitis [1]. Drug-induced liver injury is divided into two categories: toxic liver injury and atypical liver injury. The former is the drug or its metabolites directly damage the liver, and the dose of the drug, with predictability. On behalf of the drug acetaminophen, its incubation period is short, you can copy the animal model. Pathological features of hepatic lobule specific parts of liver cell necrosis. The latter for the drug haptens and liver cells in the protein-specific antigen as an antigen-presenting cells through the activation of the immune system, resulting in liver damage