论文部分内容阅读
目的分析HBV感染者四项肝纤维化血清学指标检测值与Fibroscan检测值之间的相关性。方法选择大连市第六人民医院211例HBV感染者,按肝影像学Fibroscan检测值将患者分为肝硬化组和非肝硬化组,非肝硬化组患者再根据Fibroscan分期分为无肝纤维化组、轻度肝纤维化组、中度肝纤维化组和重度肝纤维化组。所有患者均采集其相近时间内Fibroscan及Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(C-Ⅳ)、血清透明质酸(HA)、层黏连蛋白(LN)检测数据。结果运用SPSS 17.0软件进行统计学分析。结果 PCⅢ、C-Ⅳ、HA、LN检测值与Fibroscan检测值之间均具有良好的相关性(r=0.404、0.445、0.557、0.470,P<0.01),其中以HA检测值与Fibroscan检测值之间的相关性最高(r=0.557,P<0.01)。结论肝纤维化四项血清学指标检测值与Fibroscan检测值之间相关性显著。肝纤维化四项血清学指标检测在肝纤维化程度较重时的准确性更高。
Objective To analyze the correlation between the detection value of four fibrosis serological markers and Fibroscan in patients with HBV infection. Methods Totally 211 patients with HBV infection in Dalian Sixth People’s Hospital were enrolled. Patients were divided into cirrhosis group and non-cirrhosis group according to the Fibroscan detection value of liver imaging. Patients with non-cirrhosis were divided into non-hepatic fibrosis group , Mild hepatic fibrosis group, moderate hepatic fibrosis group and severe hepatic fibrosis group. All patients were collected Fibroscan and PCⅢ, C-Ⅳ, HA and LN in similar time. Results Using SPSS 17.0 software for statistical analysis. Results There was a good correlation between PCⅢ, C-Ⅳ, HA, LN and Fibroscan (r = 0.404,0.445,0.557,0.470, P <0.01) The correlation between the highest (r = 0.557, P <0.01). Conclusion There is a significant correlation between the four serological markers of liver fibrosis and Fibroscan. Four serological markers of liver fibrosis in the detection of severe degree of liver fibrosis more accurate.