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疟疾严重威胁人类的生命健康,双氢青蒿素-哌喹(科泰复)是世界卫生组织推荐的治疗无并发症恶性疟疾的首选药物,在减少其相关的发病率和死亡率方面发挥了不可或缺的作用。但随着其广泛使用后,已有研究表明在大湄公河次区域(GMS)恶性疟原虫对科泰复产生了抗药性。这严重威胁着全球疟疾防治和消除计划的实施。本文将针对恶性疟原虫对科泰复的抗药性研究以及抗药性的检测方法、抗性相关的分子标记做一综述。
Malaria is a serious threat to the health and lives of human beings. Dihydroartemisinin-pipefloxacin (Ketai-fu) is the recommended drug recommended by the World Health Organization to treat uncomplicated falciparum malaria and plays an important role in reducing its related morbidity and mortality Indispensable role. However, with its widespread use, studies have shown that P. falciparum in the Greater Mekong Subregion (GMS) is resistant to triptorelin. This is a serious threat to the global implementation of malaria control and elimination programs. In this paper, we will review the resistance of Plasmodium falciparum to Triptorevir and the detection methods of drug resistance and resistance-related molecular markers.