[Objective] The paper aimed to further observe the activity of reducing blood lipid and antioxidation effects of flavonoids from Eucommia ulmidoes Olirer leaves.[Method] ICR mice were randomly divided into the normal control group and high-fat diet group,the normal control group was fed by common feedstuffs,while high-fat diet group fed by high-fat diet,which made into tested mice of the nutrition,hyperlipidemia model.And high-fat diet groups were randomly divided into model control group,positive medicine control group,flavonoids large,medium and small-dose groups were taken medicine by flavonoids gavage with 45 mg/kg·d,15 mg/kg·d and 5 mg/kg·d dose,positive drug group was offered by Lovastatin with 5 mg/kg·d(equivalent to human dose conversion according to the standard body surface area of mice with 2 times doses),the normal control group was offered by equal volume of solvent.After 17 d,each group of mice was fasted by 12 h,orbital blood,heparin,0.2 ml of blood from each of hemolysis for the CAT after the determination of the rest of the blood and anticoagulant used for centrifugal separation of plasma lipids and POD,MDA determination.[Result] Compared with hyperlipidemia model group,TC,TG,LDL-C and AI flavonoids from Flavonoids from E.ulmidoes Olirer leaves had degraded with different degrees,HDL-C had raised,activity of CAT,POD had strengthened,content of MDA in plasma had degraded.[Conclusion] Flavonoids from E.ulmidoes Olirer leaves had effects of reducing the nutritional hyperlipemia in mice and anti-lipid oxidation. [Objective] The paper aimed to further observe the activity of reducing blood lipid and antioxidation effects of flavonoids from Eucommia ulmidoes Olirer leaves. [Method] ICR mice were randomly divided into the normal control group and high-fat diet group, the normal control group was fed by common feedstuffs, while high-fat diet group fed by high-fat diet, which made into tested mice of the nutrition, hyperlipidemia model. And high-fat diet groups were differentiated into model control group, positive medicine control group, flavonoids large, medium and small-dose groups were taken medicine by flavonoids gavage with 45 mg / kg · d, 15 mg / kg · d and 5 mg / kg · d dose, positive drug group was offered by Lovastatin with 5 mg / kg · D (equivalent to human dose conversion according to the standard body surface area of ​​mice with 2 times doses), the normal control group was offered by equal volume of solvent. After 17 d, each group of mice was fasted by 12 h, orbital blood, heparin, 0.2 ml of blood from each of hemo lysis for the CAT after the determination of the rest of the blood and anticoagulant used for centrifugal separation of plasma lipids and POD, MDA determination. [Result] Compared with hyperlipidemia model group, TC, TG, LDL-C and AI flavonoids from Flavonoids from E. ulmidoes Olirer leaves had degraded with different degrees, HDL-C had raised, activity of CAT, POD had strengthened, content of MDA in plasma had degraded. [Conclusion] Flavonoids from E.ulmidoes Olirer leaves had effects of reducing the nutritional hyperlipemia in mice and anti-lipid oxidation.