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目的 通过对血清几种炎症因子在腹腔镜手术和开腹手术治疗阑尾炎手术中水平的变化对比分析, 探讨微创技术在治疗阑尾炎的优越性.方法 收集和统计分析2015年1月—2017年1月期间睢县中医院收治的阑尾炎切除术患者102例, 采用随机数字表法将患者分为对照组, 采用传统开腹手术52例, 采用腹腔镜经脐改良单孔法阑尾切除术为实验组50例.并检测患者术前1天及术后第1天、第3天血常规白细胞计数、C-反应蛋白、降钙素原 (PCT) 以及白介素-6 (IL-6) 等炎症因子的变化情况.结果 102例手术均成功完成, 实验组均顺利完成腹腔镜单孔阑尾切除术, 无中转开放手术病例.实验组和对照组术前几种炎症因子相比无统计学意义 (P＞0.05), 术后第1天血常规白细胞计数、C-反应蛋白、降钙素原 (PCT) 以及白介素-6 (IL-6) 均显著高于术前第1 d, 实验组的升高程度小于对照组;第3 d炎症因子水平均低于术后第1天, 实验组的下降程度明显大于对照组, 两组之间比较差异有统计学意义 (P＜0.05) .结论 通过几种炎症因子的分析对比, 腹腔镜经脐改良单孔法阑尾切除术并发症少, 可明显降低术后并发症发生率, 具有明显的优越性.“,”Objective To evaluate the comparison and analysis of level changes of several kinds of serum inflammatory factors in laparoscopic surgery and open surgery for appendicitis operation, discusses the advantages of minimally invasive technique in the treatment of appendicitis. Methods Chose and statistical analyze from January 2015 to January2017 our hospital during the period of 102 patients with appendicitis resection, using the random number table method divided the patients into control group, 52 cases with traditional laparotomy, laparoscopic umbilical improvement puckering method 50 cases of appendectomy as experimental group. And detection in patients with preoperative and postoperative day 1 1 day, 3 day routine blood leukocyte count, C-reactive protein, calcitonin original (PCT) and interleukin 6 (IL-6) such as the change of inflammatory cytokines. Results Totally 102 cases were successfully completed, and the experimental group successfully completed laparoscopic appendectomy with no open surgery. The experimental group and control group compared preoperative several inflammatory factor has no statistical significance (P＞ 0. 05), postoperative day 1 routine blood leukocyte count, C-reactive protein, calcitonin original (PCT) and interleukin 6 (IL-6) were significantly higher than that of preoperative day 1, the experimental group increased degree was less than the control group; On the third day, the level of inflammatory factors was lower than the first day after surgery. The decrease of the experimental group was significantly greater than that in the control group, and there was a statistically significant difference between the two groups (P＜ 0. 05). Conclusion Through the analysis of several inflammatory factors, the complications of laparoscopic appendectomy with monomotomy can significantly reduce the incidence of postoperative complications and have obvious advantages.