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目的探讨结、直肠癌患者血脂、白细胞(WBC)和维生素E(VE)水平。方法对139例结、直肠癌住院患者和125例社区健康人群分别检测血脂水平、WBC计数和VE,并分析WBC、VE与血脂的相关性。使用单因素Logistic回归分析计算OR值。结果病例组血浆甘油三酯(TG)、极低密度脂蛋白胆固醇(VLDL-C)和WBC水平均高于对照组,而血浆高密度脂蛋白胆固醇(HDL-C)和VE水平低于对照组(P<0.05)。高TG和高WBC患结、直肠癌的OR值分别为1.757和5.897;低HDL-C患结、直肠癌OR值为2.552,有统计学意义(P<0.05)。WBC与TG、VLDL-C呈正相关(r>1),与HDL-C呈负相关(r<1);VE与HDL-C呈正相关(r>1),与TG、VLDL-C呈负相关(r<1)。结论血脂、WBC和VE可能与结、直肠癌相关。
Objective To investigate the levels of blood lipids, white blood cells (WBC) and vitamin E (VE) in patients with colorectal cancer. Methods Serum lipids, WBC count and VE were measured in 139 patients with node, rectal cancer inpatients and 125 healthy community. The correlation between WBC, VE and lipids was analyzed. OR values were calculated using one-way Logistic regression analysis. Results The levels of triglyceride (TG), VLDL-C and WBC in the patients were higher than those in the control group, while the levels of plasma HDL-C and VE were lower than those in the control group (P <0.05). OR of high-TG and high-WBC patients with colorectal cancer were 1.757 and 5.897, respectively. The OR of rectal cancer patients with low HDL-C was 2.552, with statistical significance (P <0.05). WBC was positively correlated with TG and VLDL-C (r> 1) and negatively correlated with HDL-C (r <1). VE was positively correlated with HDL-C (r <1). Conclusion Serum lipids, WBC and VE may be associated with colorectal cancer.