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目的研究雪上一枝蒿微乳中雪上一枝蒿甲素(雪甲素)体外透皮渗透性,并对其影响因素进行考察。方法采用Franz扩散池进行体外透皮渗透试验,HPLC测定雪甲素的含量,研究不同制剂、不同接收液、不同透过介质对其渗透的影响。结果雪上一枝蒿微乳中雪甲素渗透系数Kr是溶液的1.2倍,其体外透皮渗透过程更接近零级速率过程;几种接收液的透皮渗透速率无显著性差异;硝酸纤维素膜的渗透系数Kr分别是小鼠皮肤、裸鼠皮肤的2.7倍、2.6倍。结论雪上一枝蒿微乳中雪甲素体外透皮渗透较溶液渗透速率快,渗透过程更接近零级速率过程,对毒性药物的透皮吸收有重要的作用。
Aim To study the in vitro transdermal permeability of artesunate A (snow A) in the microemulsion of Artemisia selengensis and investigate its influencing factors. Methods Franz diffusion cells were used for in vitro transdermal penetration test. The contents of the three kinds of drugs were determined by HPLC. The effects of different preparations, different receiving solutions and different permeating media on their penetration were investigated. Results The osmotic coefficient of hesperidin in Artemisia annua was 1.2 times of that in solution, and the transdermal permeation in vitro was closer to zero-order rate. There was no significant difference in transdermal permeation rate among several receiving solutions. The nitrocellulose membrane The permeability coefficient Kr were 2.7 times and 2.6 times higher than that of the mouse skin and nude mice, respectively. Conclusion The in vitro transdermal permeation rate of Hedysarum in Artemisia microphylla is faster than that of the solution, and the infiltration process is closer to the zero-order rate and plays an important role in transdermal absorption of toxic drugs.